Salmon Sperm — the Latest Skincare Craze: Here’s How It Works

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Most of us would do anything to look young and youthful … but would you do this? The latest skincare trend from Korea is using salmon sperm in facial products. The male fish produce DNA compounds, which, while meant to fertilize eggs, also revitalize skin cells. You don’t have to wade into a cold mountain stream to catch a finned Casanova for your next beauty routine — these fish DNA-containing products are widely available. The question is whether you’re ready for a blast of fishy dermal vitality. 

What Is Salmon Sperm Extract? 

Salmon sperm skincare refers to polydeoxyribonucleotide (PDRN) or DNA fragments sourced from the salmon’s milt, where sperm fluid is produced. These nucleotides closely resemble human DNA, making them attractively suitable for skin repair, anti-inflammatory use and skin regeneration, specifically for wound healing. The molecules are extracted in a lab and formulated into skincare products with no residual fishiness — just bioactive dermal rejuvenation.

Why Beauty Brands and A-Listers Love It

While the Kim Kardashians of the world love applying the latest fads, beauty brands are also on board with using these fishy components in their latest skincare products. While the treatment is more potent with in-office treatments like microneedling, topical products still offer visible benefits with sustained use. 

Here’s why. 

1. Boost regeneration: PDRN activates A2 receptors, as per the above study, promoting tissue repair and faster wound healing. It’s also a popular treatment for tendon repairs and to help ease plantar fasciatis. 
2. Stimulates collagen and elastin: Regular applications and treatments are believed to enhance skin elasticity and firmness, much like red light smooths it. 
3. Hydrates and soothes: Users report improved hydration, brightness and barrier support for overall skin health in online reviews. 

Scientific Backing and Limitations

PDRN has roots in medical wound-healing research dating back as much as 25 years, and these studies all speak to its anti-inflammatory and regenerative effects and anti-aging potential. While some products claim to have FDA approval, the official verdict is still out on this. Topical applications like creams may be safer until the FDA makes a ruling on PDRN-containing products. However, many plastic surgeons and dermal clinics use these salmon fillers to plump skin and provide an instant glow-up to their clientele, often going off-label to do so. 

Cultural Origins and Celebrity Influence

Korean and Japanese brands pioneered PDRN products, especially Rejuran from Korea, which is now available in the States through online suppliers. The trend went viral in the fall of 2024 when celebrities like Jennifer Aniston, Kim Kardashian, and J-Lo shared their experiences on TikTok and Instagram. High-end salons and clinics are offering PDRN injectables at luxury price points. 

Salmon Sperm Vs Other Ingredients

PDRN complements powerhouse ingredients in anti-aging routines. Look for combinations like these:

Ingredient	Benefits	How PDRN Compares
Hyaluronic acid	Hydration, plumpness	PDRN adds regeneration and repair
Retinol	Cell turnover, collagen boost	Can enhance results when layered together
Niacinamide	Barrier support, brightening	Often used alongside in PDRN formulas
Peptides	Collagen stimulation and protein production for healing	Similar goal, but PDRN works deeper

Ideal Users for PDRN Skincare

Aging or mature skin that benefits from elasticity and reduced fine lines is a prime candidate. It’s ideal for those who need help healing from laser, microneedling or peels, and anyone with dull or dehydrated skin. Fish DNA applications may not suit people with fish allergies or vegans, and those with nickel sensitivity should exercise caution. 

Not everyone is thrilled by nature’s “miracle cure,” and since PDRN is animal-derived from fish, it’s not vegan or cruelty-free. Brands vary in transparency, with some companies using farmed salmon milt, while others rely on wild-caught sources. If you’re curious about sourcing, you should check brand policies. 

Slather Salmon Hydration on Your Skin

Below are five widely reviewed Salmon sperm products easily accessible on Amazon. 

Medicube Salmoon DNA PDRN Pink Peptide Serum

Salmon DNA can help you achieve a Korean glass glow while preventing breakouts. The product also contains several skin-boosting ingredients, such as niacinamide and peptide complexes. While it’s dermatologically tested, it and other PDRN products are not yet FDA-approved. 

Get it on Amazon

REJURAN® Turnover Ampoule

The salmon DNA is carried in a deep penetrating formula to provide cellular regeneration and skin protection. Rejuran is one of the original Korean skincare brands to use Salmon DNA. The combination of ingredients that include niacinamide, aloe vera and the hydrolyzed DNA create a powerful anti-aging product. 

Get it on Amazon

Medicube Salmon DNA PDRN Pink Collagen Jelly Gel Mask

The overnight face mask produces glass glow skin with increased elasticity, firmness and hydration. The color-changing gel lets you know when the product achieves maximum absorption. 

Get it on Amazon 

Abib PDRN Retinal Eye Patch

For targeted application, this eye patch is a jelly pad loaded with retinal, PDRN, collagen and ceramide. The curved shape makes accurate placement easy for anti-wrinkle effectiveness. 

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BRÜUN SD – Control Salmon DNA Ampoule

If you’d rather take the bold approach, this product is suited to microneedling with a derma pen, or you can apply it topically to the skin, too. It’s effective at reducing the effects of skin aging, and is more affordable than a dermatologist’s session. 

Get it on Amazon

Safety, Side Effects and Considerations

While treatments using PDRN is generally considered safe, some mild redness and sensitivity may occur. If you are allergic to fish, you may want to consult with your doctor before slathering on some salmon sperm DNA. 

More Questions About Salmon Sperm Skincare

What Exactly Is Salmon Sperm Extract in Skincare?

Salmon sperm extract, often labelled as polydeoxyribonucleotide (PDRN) or sodium DNA, is a biologically available compound sourced from the milt or sperm fluid of male salmon. It’s used in creams, serums and injectables to support skin repair, hydration and anti-aging benefits. 

Is It Safe to Use Products With PDRN on Sensitive Skin? 

Generally, yes, PDRN has anti-inflammatory properties and is often used post-procedure to soothe the skin. However, anyone with a fish allergy or highly reactive skin should patch-test first or consult a dermatologist before use. 

Is Salmon Sperm Skincare Vegan or Cruelty-Free? 

No, while some products claim this, PDRN is animal-derived and not considered vegan. While many brands try to source raw materials ethically, it’s safer to choose peptide- or botanical-based alternatives. 

How Does Salmon Sperm Compare to Retinol or Hyaluronic Acid?

PDRN isn’t a direct substitute. Instead, it complements other ingredients, which is why so many products combine fish DNA with other botanical ingredients. It’s gentler than retinol and offers regenerative benefits that hyaluronic acid alone doesn’t provide. 

How Long Until I See Results With PDRN Products?

Results vary based on the product type and skin condition. Injectables achieve faster results, while topicals generally require consistent use for four to six weeks for any visible improvement. 

Does Salmon Sperm Skincare Work?

While studies support that using PDRN can aid the skin healing, it’s unclear whether commercially available applications are as effective as the doses used in medical experiments. Whichever form of salmon skincare you use, you will need to show patience to enjoy successful results. 

Ultimately, your skin is your mirror to self-care, and if you take good care of your skin, take sunprotection steps, eat healthily and hydrate, you may not need to go as extreme as using fish DNA.