Skincare • 08/19/2025
The Benefits of Exosomes in Skin Care and 5 Top Products to Try
Revivalist is a reader-supported endeavor and our posts may contain affiliate links. When you buy through links on our site, we may earn an affiliate commission.
Social media is buzzing with talk of exosome serums and creams that promise youthful, radiant skin. But what exactly are exosomes in skincare? Why are they being seen as the next big thing? What’s the science behind the hype — and are exosomes safe to use? Here’s what we know.
What Are Exosomes? The Science Explained
Exosomes are tiny particles released by cells. They act as delivery vehicles, carrying proteins, lipids and other molecules from one cell to another. They are very important for tissue repair and immune response.
With exosomes in skin care, however, the excitement centers around the potential these tiny particles have for skin hydration, pigmentation control, wound healing, and anti-aging.
6 Key Benefits of Exosomes in Skin Care
A 2025 study published in the scientific journal Cosmetics showed that:
- Exosome-based serums and creams increased skin hydration and integrity within two to four weeks of regular use.
- Because exosomes are naturally occurring particles, they do not cause skin irritation like synthetic additives can.
- Stem cell-derived exosome creams improved skin radiance within eight weeks.
- Exosomes can be used to deliver molecules that can help to improve scars.
- The particles are effective in topical applications such as serums and in injectable form and hold promise for future use in plastic surgery as well as cosmetics.
- They may also enhance collagen production, helping to reduce wrinkles and fine lines and showcase brighter skin.
Impressive, no? However, it’s important to note that research is still largely in its early stages.
Are Exosomes Safe?
Exosomes are generally considered to be safe when used topically or administered by qualified professionals. However, in 2019, the FDA issued a warning about unapproved exosome products, particularly those marketed for unapproved use or without proper clinical trials. To date, the FDA has still not approved any exosome product.
That doesn’t mean your favorite exosome serum isn’t safe to use. It does, however, mean that you should exercise caution and not necessarily expect the claimed results. While the short-term data is certainly promising, there has not yet been any long-term research into the effects of potential risks of exosome skincare creams and products.
Most exosomes are sourced from mesenchymal stem cells, which typically means that they come from bone marrow, harvested fat cells, umbilical cord blood, placental tissue, menstrual blood or fetal membranes. This can raise concerns regarding immunological safety and ethical sourcing — however, plant-derived exosomes are also rich in biocompatible compounds that can also have potent skin rejuvenation properties, so this is another important area of ongoing research.
To be on the safe side, look for a reputable brand when choosing exosomes in skin care products, and check whether the brand is clear about the ingredients and where they are sourced.
Top 5 Exosome Skincare Products to Try
Choose from this selection of top exosome skincare products, chosen for their different price points, varying features and suitability for different skin types and beauty goals.
1. Medicube Zero Exosome Shot 7,500 PP Spicule Facial Serum
This high-end, innovative Korean serum combines a high exosome concentration with spicules, microscopic needle-like structures that act as a natural alternative to microneedling and ensure deeper penetration. It also contains the exfoliating acids, AHA, BHA and PHA.
Ideal for those seeking visible anti-aging results and improved skin texture. Great for experienced skincare consumers looking for a next level option.
2. EXODROP Exosome Cream
This cream is accessible to those who are new to exosome skincare. It is a lightweight, quick-absorbing formula with a focus on moisture and skin barrier support. It uses ginseng tree exosomes, so it is a fully vegan option that calms and soothes irritated skin and restores balance.
Ideal for sensitive skin, vegans and those just branching out into exosome skincare technology.
3. EXO SKIN SIMPLE – EXO H-SERUM Exoceuticals Hyaluronic Acid Treatment Serum
This luxury serum is a premium product with a high exosome concentration and seven different molecular weights of hyaluronic acid for deep hydration. It’s a lightweight and non-sticky formulation that glides onto your skin for inside-out nourishment and anti-aging effects.
Ideal for those seeking a science-driven product for advanced hydration and visible plumping.
4. VT COSMETICS CICA Reedle Shot 100, Spicule Microneedling Serum
This serum uses spicule micro needling technology with exosomes and cica — Centella asiatica, a tropical plant known for its soothing, anti-inflammatory and hydrating properties. It aims to remove impurities and support your skin’s natural renewal process. It also contains propolis extract for recovery and protection.
Ideal for those with sensitive or acne-prone skin who want the benefits of exosomes and gentle exfoliation.
5. Exoblanc PDRN and Exosomes Sheet Mask – 5 Pack
This sheet mask stands out for its multi-active formula, combining exosomes with PDRN — a DNA repair ingredient extracted from salmon DNA. It also contains EGF and FGF growth factors, cica for soothing and peptides for firming. This blend of regenerative and calming ingredients in a single-use mask is perfect for post-procedure care, stressed skin or a weekly skin reset.
Ideal for mature or sensitive skin or those seeking a spa-like treatment at home.
Is Exosome Skin Care Your Next Beauty Breakthrough?
Exosome skin care is quickly moving from buzzword to beauty must-have, offering science-backed benefits for those seeking real results. Whether you’re after deep hydration, skin renewal or a gentle boost for sensitive skin, there’s an exosome skincare product to fit your needs and budget.
As with any new trend, it’s smart to do your research, patch test, and consult with a skincare professional if you have concerns. Ready to see what exosomes can do for your glow? The future of skin care is here — why not give it a try?
Subscribe to Our Weekly Newsletter
We would love to connect deeper with you!
Author
Chloe Powell
Chloe is the Senior Editor at Revivalist, where she pours her heart into every piece of content. Her dream is to inspire others to live full, happy, and balanced lives. While she specializes in beauty and wellness, she’s passionate about all aspects of women’s lifestyle and loves helping others shine with confidence.
